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Jožef Stefan
International
Postgraduate School

Jamova 39
SI-1000 Ljubljana
Slovenia

Phone: +386 1 477 31 00
Fax: +386 1 477 31 10
Email: info@mps.si

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Course Description

Organic Analysis

Program

Ecotechnologies, third-level study programme

Lecturers:

prof. dr. Ester Heath

Goals:

The course is devoted towards understanding the basic analytical methods applied in organic analysis. We will provide the students with a comprehensive introduction to analytical chemistry techniques as well as knowledge of instrumentation. Besides lectures and seminars an important part of this course will be devoted to practical workshops, where the students will gain experience in solving analytical problems.

Content:

The course will the cover the main techniques involved in the
a) Separation and
b) Identification of organic compounds.
SEPARATION METHODS
In the separation part we will cover separation on the basis of compound physical properties (liquid-liquid extraction, solid phase extraction and solid phase micro-extraction, Soxhlet extraction, microwave assisted extraction, supercritical fluid extraction) and chromatographic separation (gas and liquid chromatography, supercritical fluid chromatography, capillary electrophoresis and electrochromatography). The principles of green chemistry related to extraction methods will be also discussed.
IDENTIFICATION METHODS
Identification of organic compounds will cover different spectroscopic methods including UV-VIS, IR, RAMAN, and NMR with an emphasis on mass spectrometry and hyphenated chromatographic spectroscopic techniques.

Course literature:

D.A. Skoog, D.M. West, F.J. Holler: Fundamentals of Analytical Chemistry, Sounders College Publishing, Forth Worth, 1992.

D.A. Skoog, D.M. West, F.J. Holler: Principles of Instrumental Analysis, Thomson Learning, 5th edition, 1998.

J. McMurry: Organic Chemistry, Brooks Cole Publishing Company, 1988.

K. Robards, P.R. Haddad, P.E. Jackson: Principles and Practice of Modern Chromatographic Methods, Academic Press, London, 2002.

Significant publications and references:

HEATH, Ester, LESKOVŠEK, Hermina. Isolation and identification of fluoranthene biodegradation products. Analyst (Lond.), 1999, vol. 124, str. 1765-1769.

HERNANDO, M. D., HEATH, Ester, PETROVIĆ, Mira, BARCELÓ, Damia. Trace-level determination of pharmaceutical residues by LC-MS/MS in natural and treated waters, A pilot-survey study. Anal. bioanal. chem., 2006, vol. 385, str. 985-991.

HEATH, Ester, OGRINC, Nives, FAGANELI, Jadran, COVELLI, Stefano. Sedimentary record of polycyclic aromatic hydrocarbons in the Gulf of Trieste (Northern Adriatic Sea). Water, air & soil pollution, Focus, 2006, vol. 6, št. (5/6), str. 605-614.

KOSJEK, Tina, HEATH, Ester, PETROVIĆ, Mira, BARCELÓ, Damia. Mass spectrometry for identifying pharmaceutical biotransformation products in the environment. TrAC, Trends anal. chem. (Regul. ed.), 2007, vol. 26, no. 11, str. 1076-1085.

KOSJEK, Tina, ŽIGON, Dušan, KRALJ, Bogdan, HEATH, Ester. The use of quadrupole time-of-flight mass spectrometer for the elucidation of diclofenac biotransformation products in wastewater. J. chromatogr., [in press] 2008, 7 str.

KOSJEK, Tina, HEATH, Ester. Applications of mass spectrometry to identifying pharmaceutical-transformation products in water treatment. TrAC, Trends anal. chem. (Regul. ed.), 2008, issue 10, vol. 27, str. 807-820.

Examination:

Seminar and written/oral exam.

Students obligations:

Seminar and written/oral exam.

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