MPŠ MP&Scaron MP&Scaron MP&Scaron Avtorji

Jožef Stefan
Postgraduate School

Jamova 39
SI-1000 Ljubljana

Phone: +386 1 477 31 00
Fax: +386 1 477 31 10


Course Description

Biology of Stem Cells


Nanosciences and Nanotechnologies, third-level study programme


prof. dr. Tanja Dominko
dr. Helena Motaln


- Students acquire knowledge of basic characteristics of different types of stem cells.
- Understanding of modern molecular techniques in stem cell research
- Understanding the role of stem cells in different diseases.


Biology of Stem Cells
I. Stem cells in development and regeneration
1. Embryogenesis and embryonic stem cells (biochemical and biological processes)
2. Induced stem cells –pluripotency induction
3. Stem cells in tissue engineering
4. Stem cells - ethics and politics

II Stem cells in disease
1. Potential of stem cells application in various diseases
2. Transformation vs. (de-) differentiation
3. Cancer stem cells
4. Stem cell products - state of the art technologies

Course literature:

Ulrich Henning (ed): Perspectives of Stem Cells, Springer, ISBN: 978-90-481-3375-8
Vinagolu K. Rajasekhar (ed), Mohan C Vemuri: Regulatory Networks of Stem Cells, Springer, ISBN: 978-1-60327-226-1

Significant publications and references:

Ambady, S., Kashpur, O., Kole, D., Malcuit, C., Holmes, W.F., Page, R., and T. Dominko (2010). Embryonic NANOG and its pseudogene NANOG P8 are expressed in a variety of human cells. Int J Dev Biol. 2010 Nov 19. [Epub ahead of print]PMID: 21136380.
Dominko, T. (2010). Cellular reprogramming: Current technology/perspectives and generation of induced pluripotent cells. In: Human Stem Cell Technology and Biology: A Research Guide and Laboratory Manual. Wiley-Blackwell Publishers, (Stein, G.S. et al., Editors), pp 297-310.
Page, R., Holmes, W.F., Kole, D., Huntress, V., Vilner, L., Ambady, S., Kashpur, O., Vojtic, I., Whitton, H. and T. Dominko (2009). Induction of stem cell gene expression in adult human dermal fibroblasts without transgenes. Cloning and Stem Cells, 11:417-426.


- Oral exam of the basic theoretical part (30%)
- Seminar assessment (30%)
- Interactive involvement in practical work (40%)

Students obligations:

Oral exam, seminar and interactive involvement in practical work.