MPŠ
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Jožef Stefan
International
Postgraduate School

Jamova 39
SI-1000 Ljubljana
Slovenia

Phone: +386 1 477 31 00
Fax: +386 1 477 31 10
Email: info@mps.si

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Course Description

Selected Topics in Biophysics

Program

Nanosciences and Nanotechnologies, third-level study programme

Lecturers:

prof. dr. Gojmir Lahajnar

Goals:

Students learn principles of biophysics and thus become competent to solve the interdisciplinary research problems.

Content:

• STRUCTURE AND PROPERTIES OF WATER:
H2O molecule. Hydrogen bond. Structure of ice and liquid water. Water as solvent and its role in intermolecular interactions of biomolecules. Hydrofobic interaction. Ionization of water. Spectroscopic information about water structure.
• THERMODYNAMICS AND BIOLOGY:
Elements of classical thermodynamics. Thermodynamic potentials. Thermodynamic equilibrium: multi-component systems. chemical equilibrium, ligand binding to macromolecules. Thermodynamics of redox processes.
• FREE ENERGY OF BIOLOGICAL OXIDATION - GENERATION AND STORAGE:
Free energy yield: glycolysis, citric acid cycle. Chemiosmotic mechanism.
• TRANSPORT PHENOMENA:
Diffusion: continuity equation, Fick’s laws. Diffusion across porous membranes, membrane permeability. Properties of biological membranes: permeability, selectivity, specificity. Concept of active transport across biomembranes. Transport in continuous systems. Nernst-Planck electrodiffusion equation, diffusion potential.

Course literature:

Price N., Dwek R., Ratcliffe G., Wormald M.. Principles and Problems in Physical Chemistry for Biochemists, 424 pages, Oxford University Press, USA 3 edition (2002), ISBN: 0198792816.

Sybesma C., Biophysics. An Introduction. 332 pages, Springer, 1 edition (1989), ISBN: 0792300297.

Eisenberg D., Kauzmann W..The Structure and Properties of Water. 296 pages, Oxford University Press (1985), ISBN: 0195003217.

Adam G., Läuger P., Stark G.. Physikalische Chemie und Biophysik, 617 pages, Springer; 4 edition (2003), ISBN: 3540000666. lag

A. Vilfan in G. Lahajnar, Zbirka računskih vaj iz biofizike z nakazanimi rešitvami, Študentska založba, Ljubljana, 2007.

Significant publications and references:

LAHAJNAR, Gojmir, PEČAR, Slavko, SEPE, Ana. Na-nitroprusside and HgCl[sub]2 modify the water permeability and volume of human erythrocytes. Bioelectrochemistry. [Print ed.], 2007, vol. 70, str. 462-468. [COBISS.SI-ID 20130855]

BAUMGARTNER, Saša, LAHAJNAR, Gojmir, SEPE, Ana, KRISTL, Julijana. Quantitative evaluation of polymer concentration profile during swelling of hydrophilic matrix tablets using 1H NMR and MRI methods. Eur. j. pharm. biopharm.. [Print ed.], 2005, vol. 59, no. 2, str. 299-306. [COBISS.SI-ID 1677425]

SEPE, Ana, BAUMGARTNER, Saša, KRISTL, Julijana, LAHAJNAR, Gojmir, JARH, Orest. Quantification of the MR images of hydrogels by NMR relaxation measurements. Cell. Mol. Biol. Lett., 2002, vol. 7, no. 1, str. 154-156. [COBISS.SI-ID 1105265]

LAHAJNAR, Gojmir, MAČEK, Peter, ZUPANČIČ, Ivan. Suppression of red cell diffusional water permeability by lipophilic solutes. Bioelectrochem. bioenerg.. [Print ed.], 2000, vol. 52, str. 179-185. [COBISS.SI-ID 15589927]

Examination:

Seminar and oral exam.

Students obligations:

Seminar and oral exam.

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