MPŠ
MPŠ MP&Scaron MP&Scaron MP&Scaron Avtorji

Jožef Stefan
International
Postgraduate School

Jamova 39
SI-1000 Ljubljana
Slovenia

Phone: +386 1 477 31 00
Fax: +386 1 477 31 10
Email: info@mps.si

Search

Course Description

Nanobiophysics

Program

Nanosciences and Nanotechnologies, third-level study programme

Lecturers:

prof. dr. Janez Štrancar
prof. dr. Igor Serša

Goals:

Students become acquainted with the latest achievements in the use of developed nanostructures in biological systems and nanobiophysics, particularly with respect to membrane physics, cell physics and biomotor features of macromolecules. Special emphasis will be laid on the use of electron spin resonance methods and NMR for the study of biosystems at the nano level, particularly with respect to analogies between the operation of tested natural nanostructures and technologically promising complements.

Content:

· Structure and physics of lyotropic systems.
· Structure and biophysics of biological macromolecules and their communities.
· Interactions between lipids and proteins.
· Structure and membrane biophysics.
· Nanoparticles in cellular processes.
· Biomotors and contractile systems.
· Planning of spin markers for electron spin resonance of biosystems and their interaction with technological nanoparticles.
- double microspectroscopy and membrane

Course literature:

The latest articles from following journals: Science, Nature and Physical Review Letters.

C. P. Poole Jr.: Electron spin resonance, 2nd ed, Dover Public. Inc., Mineola, 1983

P. T. Callaghan: Principles of Nuclear Magnetic Resonance Microscopy, Oxford University Press, 1993, Oxford

C. M.. Niemeyer, C. A. Mirikin: Nanobiotechnology, Wiley-VCH, Singapur, 2007

Ferry, David K.; Joint Author Goodnick, Stephen M.: Transport In Nanostructures, Cambridge University Press, 1999

T.A. Waigh: Applied Biophysics, Wiley, Chichester, 2007.

J. R. Lakowicz: Principles of Fluorescence Spectroscopy, Springer, Singapor 2006.

I. N. Serdyuk, N. R. Zaccai, J. Zaccai : Methods in Molecular Biophysics, Camriudge Univ. Press, 2007.

A. H. Zewail: Physical Biology, from atoms to medicine, Imperial College Press, London 2008.

Significant publications and references:

ŠTRANCAR, Janez, KOKLIČ, Tilen, ARSOV, Zoran. Soft picture of lateral heterogeneity in biomembranes. J Membr Biol, 2003, vol. 196, str. 135-146.

RAPPOLT, Michael, AMENITSCH, Heinz, ŠTRANCAR, Janez, TEIXEIRA, Cilaine V., KRIECHBAUM, Manfred, PABST, Georg, MAJEROWICZ, Monika, LAGGNER, Peter. Phospholipid mesophases at solid interfaces : in situ- X-ray diffraction and spin-label studies. Adv. colloid interface sci.. [Print ed.], 2004, vol. 111, str. 63-77.

ŠTRANCAR, Janez, KOKLIČ, Tilen, ARSOV, Zoran, FILIPIČ, Bogdan, STOPAR, David, HEMMINGA, Marcus A. Spin label EPR-based characterization of biosystem complexity. J. chem. inf. mod., 2005, vol. 45, no. 2, str. 394-406.

STOPAR, David, ŠTRANCAR, Janez, SPRUIJT, Ruud B., HEMMINGA, Marcus A. Motional restrictions of membrane proteins : a site-directed spin labeling study. Biophys. j., 2006, vol. 91, no. 9, str. 3341-3348.

PABST, Georg, HODŽIĆ, Aden, ŠTRANCAR, Janez, DANNER, Sabine, RAPPOLT, Michael, LAGGNER, Peter. Rigidification of neutral lipid bilayers in the presence of salts. Biophys. j., 2007, vol. 93, no. 8, str. 2699-2696.

ŠTRANCAR, Janez, ARSOV, Zoran. Application of spin-labeling EPR and ATR-FTIR spectroscopies to the study of membrane heterogeneity. V: OTTOVA-LEITMANNOVA, Angelica (ur.). Advances in planar lipid bilayers and liposomes. Vol. 6. Amsterdam [etc.]: Academic Press, Elsevier Science, cop. 2008, str. 139-163.

ŠTRANCAR, Janez. Advanced ESR spectroscopy in membrane biophysics. V: BERLINER, Lawrence J. (ur.), HEMMINGA, Marcus A. ESR spectroscopy in membrane biophysics, (Biological magnetic resonance, vol. 27). New York: Springer, cop. 2007, str. 49-89.

Examination:

Type (examination, oral, coursework, project):
• seminar and oral exam

Students obligations:

• seminar and oral exam

Links: