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Jožef Stefan
International
Postgraduate School

Jamova 39
SI-1000 Ljubljana
Slovenia

Phone: +386 1 477 31 00
Fax: +386 1 477 31 10
Email: info@mps.si

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Course Description

Protoeolytic Enzymes and Their Inhibitors in Diagnosis and Therapy of Cancer

Program

Nanosciences and Nanotechnologies, third-level study programme

Lecturers:

prof. dr. Tamara Lah Turnšek

Goals:

During the first year, the students in acquainted with the basics of tumour biology and experimental oncology. The students gets the knowledge on molecular changes, responsible for the initiation of malignant transformation of the cell as well as on specific biological properties of various types of tumours. The students gets the understanding of basic principles of prevention, diagnosis, prognosis and therapy in oncology. In the second part, the students gets the knowledge on proteolysis and its role in carcinogenesis and cancer progression.
To understand the concept of research methodology in life sciences and in particular in biomedicine.

To learn experimental approaches in diagnosis and prognosis of cancer.

Content:

The course is divided in several themes in the field of tumour biology:
- Epidemiology of cancer and the factors contributing to carcinogenesis and preventive measures;
- Carcinogenesis: molecular changes in tumour cells (oncogenes, tumour suppressor genes);
- Tumour cell characteristics: benign and malignant tumours;
- Characteristics of tumour growth and angiogenesis as well as steps in metastasis;
- Proteolytic enzymes and their inhibitors: their role in all steps of tumour progression;
- Experimental oncology: diagnostics, models, etc.;
- Principles of cancer therapy.

Course literature:

Tannock IF, Hill RP, Bristow RG, Harrington L. The Basic Science of Oncology, McGraw-Hill Medical Publishing Division, 2005. ISBN- 0-07-138774-9 ;
Weniberg RA- The Biology of Cancer,, Garland Science, Taylor & Francis Grouip. LLC.USA., 2007 , ISBN: 0-8153-4078-8
Dylan E et al. (eds): Cnacerdegradome - Proteases and Cancer biology, Springer, ISBN-978-0-387-69056-8
Nature Reviews Cancer – review articles on selected topics

Significant publications and references:

LAH TURNŠEK, Tamara, NANNI, Isabelle, TRINKAUS, Miha, METELLUS, Philipe, DUSSERT, Christophe, RIDDER, Leo de, RAJČEVIĆ, Uroš, BLEJEC, Andrej, MARTIN, Pierre-Marie. Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors. J. neurosurg., 2010, vol. 112, no. 5, str. 940-950. http://dx.doi.org/10.3171/2009.7.JNS081729, doi: 10.3171/2009.7.JNS081729. [COBISS.SI-ID 2079567], [JCR]
GOLE, Boris, HUSZTHY, Peter C., POPOVIĆ, Mara, JERUC, Jera, ARDEBILI, Seyed Yousef, BJERKVIG, Rolf, LAH TURNŠEK, Tamara. The regulation of cysteine cathepsins and cystatins in human gliomas. Int J Cancer, 2012, 20 str., [in press], doi: 10.1002/ijc.27453. [COBISS.SI-ID 2542159], [JCR]
MOTALN, Helena, SCHICHOR, Christian, LAH TURNŠEK, Tamara. Human mesenchymal stem cells and their use in cell-based therapies. Cancer (Print), 2010, vol. 116, no. 11, str. 2519-2530. http://dx.doi.org/10.1002/cncr.25056, doi: 10.1002/cncr.25056. [COBISS.SI-ID 2201167], [JCR]

Examination:

Oral exam (70 %)
Presentation of the seminar (30 %)

Students obligations:

Attend lectures, contribute to class discussion and prepare the seminar.

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