DEFENCE OF THE DOCTORAL DISSERTATION BY GIULIA DELLA PELLE

Defence of the Doctoral Dissertation by Giulia Della Pelle

IPS invites you to the Defence of the Doctoral Dissertation by Giulia Della Pelle titled: Bio-inspired nanocarriers for therapeutic nucleic acid delivery. The defence will take place on Thursday, 27 November 2025, at 12:30 p.m. at the Kolar Lecture Hall, JSI, Jamova 39, Ljubljana. You can also join the defence via the following link: Zoom, Meeting ID: 836 8807 0285, Passcode: 736840.

Supervisor: Asst. Prof. Nina Kostevšek.

Short summary:

In this, dissertation bioinspired nanocarriers for efficient siRNA delivery were developed, addressing challenges in pharmacokinetics, immune evasion, and targeting. Erythrocyte membrane vesicles and genipin-crosslinked nanoparticles were engineered, alone and combined, for stealth, fluorescence, and tumor-specific delivery. The systems achieved effective gene knockdown with low toxicity, advancing non-viral gene therapy. Integrating nanotechnology, pharmacology, and materials science, this work presents a multifunctional platform for precise, biocompatible RNA-based treatments and outlines future prospects for clinical translation.

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