Search Results (29)
Development of silicon carbide based implants with improved biocompatibility and mechanical properties
With emerging need for orthopaedic implants and prolonged exposure of organism to implants also problems connected to elution of metal ions that in some cases cause adverse reactions in the human body, emerge. The main aim of our work was therefore to investigate the potential of silicon carbide (SiC) to …
Contribution to understanding of the mechanism of amyloid fibril formation and its effects on the cell
The presence of insoluble amyloid aggregates in various human tissues correlates with the development of many human disorders (amyloidoses), including neurodegenerative diseases. Deposition of the aggregated misfolded proteins in the brain, where aggregates can be localized extracellularly or intracellularly, is the main characteristic of Alzheimer's, Parkinson's, Huntington's, prion diseases and …
Hydraulic load cells for measurement of small loads
This work deals with the design of a small kitchen appliance with a weighing function integrated into a control loop in order to prevent unbalanced movement of the appliance during operation. In this particular case, the weighing should be appropriate for larger amounts (up to 5 kg) of ingredients. The …
Effect of ingested nanofibers and nanoparticles on digestive gland epithelium of a model test organism
Engineered nanofibers and nanoparticles are recognized as capable of inducing cellular perturbations according to the oxidative stress paradigm or by interacting directly with biological membranes. A number of authors in their investigations with the nanofibres and nanoparticles has reported the ability of nanofibers and nanotparticle to cause the different damage …
Colloidal Interactions and Novel Colloidal Structures in Thin Nematic Layers
The thesis presents experimental studies of colloidal interactions and novel colloidal structures in confined nematic liquid crystal using optical tweezers. Liquid crystal colloids are a novel class of composite materials with well-controlled periodic structures in the nanometer and micrometer ranges. Moreover, they also posses novel mechanical, optical and rheological properties, …
Role of Cysteine Cathepsins in the Processing, Activation and Inactivation of Perforin
Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) recognize virus-infected or malignant transformed cells and destroy them through two independent mechanisms. Apoptotic target-cell death can be triggered by the engagement of death-receptors or by the release of cytotoxic granules. Cytotoxic granules gather at the site of contact between the …
The synthesis and characterization of BaO-rich phases within the BaO-Nb2O5 and BaO-WO3-Nb2O5 systems
This PhD thesis presents experimental results from the synthesis, crystal structure and microwave dielectric characterization of BaO-rich phases within the BaO-Nb2O5 and BaONb2O5- WO3 system. I was primarily interested in two compounds with unknown crystal structure, i.e., the binary Ba4Nb2O9 and the ternary Ba6Nb2WO14, which lie on a common virtual …
Role and significance of cysteine cathepsins in different models of apoptosis
Programmed cell death is a highly organized process by which multicellular organisms eliminate damaged, superfluous and potentially harmful cells. Apoptosis is the most studied form of programmed cell death. It is characterized by typical morphological and biochemical changes which are a consequence of activation of cysteine proteases, caspases. Apoptosis is …
Modular gene dynamics and network theory at mesoscopic scale
Complex dynamical systems are often modeled as networks, with nodes representing dynamical units which interact through the network’s links. Gene regulatory networks, responsible for the production of proteins inside a cell, are an example of system that can be described as a network of interacting genes. The behavior of a …