Search Results (39)
Development of methods for electrostatic immobilization and coupling different microbial cells
Naturally formed microbial communities are present in the form of cellular aggregates that create a set of diverse biochemical pathways through cross-feeding between the members of the microbial community. One of the most important factors so that some biochemical reactions can occur is the appropriate spatial placement of a particular …
In silico approaches to understand and predict the ligand-binding interactions of the human P-glycoprotein (ABCB1) membrane transporter
The P-glycoprotein (P-gp) is responsible for the elimination of a wide variety of substances from the cell, thus it is thought to play an important role in detoxification functions. The P-gp also affects the ADMET (absorption, distribution, metabolism, excretion, and toxicity in pharmacokinetics) properties of drugs. It is involved in …
Vacuum metrology and the role of surface conditions on the tangential momentum accommodation of molecules in a rarefied gas
The interactions between gas molecules and a surface strongly affect the behaviour of systems in a large array of research fields, such as vacuum science and metrology, microfluidics, particle physics, and nuclear physics. In this work, focus is given to the momentum accommodation of gas molecules. The parameter used in …
Detection of anomalous and suspicious behavior patterns from spatio-temporal agent traces
Many applications, including smart environments, surveillance, human-robot interaction, and ambient assisted living, involve the problem of learning patterns of agent behavior from sensor data. Deviant behavior is a pattern in the data that either does not conform to the expected behavior, that is, anomalous behavior, or matches previously defined unwanted …
Spectroscopic characterization of conformations of short alanine peptides, poly-L-lysine and insulin during formation of amyloid fibrils
The process of protein folding describes the transition by which an unordered polypeptide chain attains its functional native three-dimensional structure. A detailed understanding of the principles which govern the protein folding, such as conformational preferences of amino acid residues, the neighbour residue effect and the solvent effects, remains an important …
Investigation of heterogeneous reactions of trifluoromethane with some metal oxides, hydroxides and carbonates
Heterogeneous reactions of trifluoromethane CHF3 with solid xerogel oxides, alkali hydroxides and carbonates were investigated under static and dynamic conditions and at moderate temperatures. In all cases, main reaction is fluorination characterised by a complete decomposition (mineralisation) of the fluorinating agent, CHF3, and the formation of the solid metal fluorides. …
Sonochemical synthesis and characterization of hydroxyapatite/metal-based composite materials for biomedical applications
A new approach for the synthesis of silver (Ag), platinum (Pt) and gold (Au) nanoparticles and their composites with hydroxyapatite (HAp) is developed via a sonochemical process. The major goal was to design physicochemical properties of material in order to achieve: (i) intensive antibacterial activity and (ii) maximal reduction of …
Development of new anti-bioadhesive surfaces for specific neurodegenerative agents
The research work presented in this thesis considers the development of new biocompatible surfaces that are able to control the adhesion of specific proteins responsible for the development of neurodegenerative diseases such as Creutzfeldt–Jakob, Alzheimer, Parkinson and Lewis body disease. Our approach was focused on problems prior to the detection …
Semi-automatic ontology construction
This thesis addresses the task of formalizing and implementing the process of semi-automatic ontology construction. We propose a theoretical framework for formalizing the ontology construction process. The process is described as a sequence of operators applied to the ontology. Several types of common operators are identified and each type is …
Effect of ingested nanofibers and nanoparticles on digestive gland epithelium of a model test organism
Engineered nanofibers and nanoparticles are recognized as capable of inducing cellular perturbations according to the oxidative stress paradigm or by interacting directly with biological membranes. A number of authors in their investigations with the nanofibres and nanoparticles has reported the ability of nanofibers and nanotparticle to cause the different damage …