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Quantitative imaging of cisplatin in tumour samples by laser ablation inductively coupled plasma mass spectrometry

Author(s): Stefan Marković (Author), Janez Ščančar (Supervisor), Janja Vidmar (Co-Supervisor)

Year: 2022

Type: Doctoral dissertation

Medicine relies on imaging techniques such as ultrasound, magnetic resonance, computed tomography and histopathological image analysis because they provide valuable data needed for the diagnosis and treatment of diseases and injuries. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is often used in research and for the advanced diagnosis and …

Speciation of ruthenium-based candidate drugs for cancer treatment and copper as a potential biomarker for cancer diagnosis in human serum

Author(s): Katarina Marković (Author), Radmila Milačič (Supervisor)

Year: 2022

Type: Doctoral dissertation

According to the World Health Organization (WHO), cancer represents the second leading cause of mortality, with almost 10 million deaths in 2020. A broad spectra of cancer treatments are being developed, among them are metal-based drugs. Consistent with the available data, platinum (Pt)-based chemotherapeutics are still widely used to treat …

Method for the determination of uranium isotope ratios and its application as a novel geochemical tracer

Author(s): Leja Rovan (Author), Marko Štrok (Supervisor)

Year: 2021

Type: Doctoral dissertation

U and Th isotopic composition have been proven to be a valuable tool in environmental science, oceanography, hydrology, geology, nuclear forensics, and science-based archaeology. These applications require simultaneous detection of both minor and major isotopes at high accuracy. Often, the amount of sample or concentration of U and Th are …

Environmental impacts of building materials containing by-products from steel industry

Author(s): Tina Oblak (Author), Janez Ščančar, (Supervisor), Radmila Milačič (Co-Supervisor)

Year: 2013

Type: Doctoral dissertation

Recycling and reuse of waste by-products from steel industry is a common practice worldwide, which is in the last decade becoming more and more established also in Slovenia. Wastes from steel-making industry can be reused as alternative materials to successfully replace natural raw materials in asphalt mixes and in numerous …

Organic geochemistry of stratified eutrophic alpine lakes (Lake Bled)

Author(s): Marinka Gams Petrišič (Author), Nives Ogrinc (Supervisor)

Year: 2013

Type: Doctoral dissertation

The identification and quantification of organic compounds present in the environment is a major area of application in modern analytical chemistry. However, it is still scarcely recognized that, in addition to the chemical identity and concentration of organic compounds, there is more information to be found about their source and …

Sintering and phase transition behaviour of sodium niobate

Author(s): Jurij Koruza (Author), Barbara Malič (Supervisor), Tadej Rojac (Co-Supervisor)

Year: 2013

Type: Doctoral dissertation

Sodium niobate (NaNbO3) is the end member of several alkaline niobate-based solid solutions, which represent an important group of environment-friendly lead-free piezoceramics. Even though alkaline niobates are of considerable technological importance, problems in obtaining high densities and a fine-grained microstructure are still reported and not much is known about the …

Speciation of aluminium in human serum by CIM® (Convective Interaction Media) monolithic chromatography and mass spectrometry

Author(s): Simona Murko (Author), Janez Ščančar (Supervisor), Radmila Milačič (Co-Supervisor)

Year: 2010

Type: Doctoral dissertation

The toxicity, biological availability and mobility of aluminium (Al) depend on its chemical form. In order to understand toxicity and transport of Al in human body it is important to identify and quantify Al species present in human serum. This led to the development of sensitive and selective analytical methods …