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Comparative View into Protease - Inhibitor Interaction

Author(s): Miha Renko (Author), Dušan Turk (Supervisor)

Year: 2010

Type: Doctoral dissertation

Interactions between macromolecules are the basic events of life. Their characterization is thus a key to understanding the physiology and the underlying specificity of these events. Not only understanding of the final states (where the molecules get closest together), also understanding of the course of approach is mandatory to gain …

Selenocompounds in selenium-enriched plants determined by spectrometric methods

Author(s): Petra Cuderman (Author), Vekoslava Stibilj (Supervisor)

Year: 2010

Type: Doctoral dissertation

Selenium (Se) has been demonstrated to be an essential trace element for maintenance of animal and human health. Se is incorporated into proteins to make selenoproteins, which are important antioxidant enzymes. The antioxidant properties of selenoproteins help to prevent cellular damage caused by radicals. Radicals are natural by-products of oxygen …

Regulation of cysteine proteases cathepsins B, S and K and their role in inflammatory processes

Author(s): Urška Požgan (Author), Boris Turk (Supervisor)

Year: 2010

Type: Doctoral dissertation

Proteases are responsible for enzymatic cleavage of peptide bonds, which is a basic requirement for completion of diverse biological processes.The proteolytic activity of proteases must be rigorously controlled to avoid inappropriate degradation of proteins. Imbalance in regulation of proteolytic activity can be found in a wide range of diseases. Degradation …