Solving real-life optimization problems numerically is often very time demanding, because of high complexity of the simulations that are usually involved. Solving such problems becomes highly impractical for this reason and can even lead to use of less complex and also less accurate models. Fortunately, evolutionary algorithms, often used in …
The problem of structure determination of membrane proteins is addressed with a new combination of site-directed spin labelling (SDSL) electron paramagnetic resonance (EPR) spectroscopy and structure modelling of a protein and its conformational spaces. This new approach is aimed at structural characterization of membrane proteins and intrinsically disordered proteins. In …