DEFENCE OF THE DOCTORAL DISSERTATION BY PETRA MATJAN ŠTEFIN

Defence of the Doctoral Dissertation by Petra Matjan Štefin

IPS invites you to the Defence of the Doctoral Dissertation by Petra Matjan Štefin titled: The impact of stefin B and cystatin C deficiency on cancer progression and tumor microenvironment in a mouse breast cancer model. The defence will take place on Wednesday, 23 September 2026, at 2:00 p.m. at the IPS Lecture Room (N205-N206, Jamova c. 39, 1000 Ljubljana). You can also join the defence via the following link: Zoom, Meeting ID: 826 2007 0694, Passcode: 869898.

Supervisor: Dr. Georgy Mikhaylov.

Co-Supervisor: Prof. Dr. Olga Vasiljeva.

Short summary:

Stefin B and cystatin C are inhibitors of cysteine cathepsins that influence breast cancer progression. In our study, using a double-knockout mouse model, we showed that loss of both inhibitors slows tumor growth, reduces lung metastases, and reprograms immune cells toward an anti-tumor state, revealing their critical combined role in regulating disease.

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