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Development of an alternative approach to membrane protein structure determination based on the analysis of local rotational conformational spaces

Author(s): Aleh Kavalenka (Author), Janez Štrancar (Supervisor)

Year: 2009

Type: Doctoral dissertation

The problem of structure determination of membrane proteins is addressed with a new combination of site-directed spin labelling (SDSL) electron paramagnetic resonance (EPR) spectroscopy and structure modelling of a protein and its conformational spaces. This new approach is aimed at structural characterization of membrane proteins and intrinsically disordered proteins. In …