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Effect of N-glycosylation on plasma glutamate carboxypeptidase function

Author(s): Dejan Suban (Author), Vito Turk (Supervisor), Iztok Dolenc (Co-Supervisor)

Year: 2012

Type: Doctoral dissertation

Plasma glutamate carboxypeptidase (PGCP) is a metalloproteinase. It is able to hydrolyze dipeptides into free amino acids. The enzyme is involved in the release of hormone thyroxin (T4) from Thyroglobulin (Tg), as suggested by thyroid gland studies. Prediction from the primary structure of human PGCP suggests the presence of five …