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Production and characterization of MHC class II invariant chain complex

Author(s): Dušana Majera (Author), Dušan Turk (Supervisor), Jaques Neefjes (Co-Supervisor)

Year: 2012

Type: Doctoral dissertation

Major histocompatibility complex (MHC) class II molecules are polymorphic cell surface glycoproteins expressed only on the surface of the professional antigen presenting cells and they play a crucial role in the adaptive immune responses. MHC class II molecules undergo a very complex maturation process. They are synthesized in the endoplasmic …