Latest Academic Works
In vitro-detected early events to unravel late-onset neurodegeneration
Alzheimer's disease (AD) is the most prevalent form of dementia, ranking as the 7th deadliest world’s disease. Over 99% of cases are triggered by unknown environmental factors. Despite decades of research, the exact cause remains elusive, and effective treatments are yet to emerge. Recent epidemiological evidence strongly links cognitive decline …
Investigating the early molecular events following exposure of lung cells to nanoparticles using advanced optical microscopies
The potential toxicity of nanoparticles in our environment and consumer products is currently determined by costly and timely animal-based testing, which limits the rate of nanoparticle testing, causing a desperate need for alternative testing strategies. A promising alternative – mechanism-based prediction – employs a set of high-throughput cell-based tests that …
Effect of coupling between external factors and building materials' properties on living conditions deterioration in low-energy buildings
Buildings are complex systems as external factors are linked to, and have an effect on the characteristics of a building. In this dissertation, the focus is on the connection between external factors and the building’s characteristics, which have an impact on the living conditions, durability and energy efficiency of a …
Development of an alternative approach to membrane protein structure determination based on the analysis of local rotational conformational spaces
The problem of structure determination of membrane proteins is addressed with a new combination of site-directed spin labelling (SDSL) electron paramagnetic resonance (EPR) spectroscopy and structure modelling of a protein and its conformational spaces. This new approach is aimed at structural characterization of membrane proteins and intrinsically disordered proteins. In …