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Role of Cysteine Cathepsins in the Processing, Activation and Inactivation of Perforin
Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) recognize virus-infected or malignant transformed cells and destroy them through two independent mechanisms. Apoptotic target-cell death can be triggered by the engagement of death-receptors or by the release of cytotoxic granules. Cytotoxic granules gather at the site of contact between the …