Search Results (4)
Role and significance of cysteine cathepsins in TRAIL induced apoptosis
Apoptosis is an innate mechanism by which a multicellular organisms eliminates unwanted, damaged and potentially harmful cells. During apoptosis inflammation of the surrounding tissues is prevented. Defects in an apoptotic signaling can lead to numerous pathological conditions. Apoptosis is mediated through two main pathways, the extrinsic or the death receptor …
Role of Cysteine Cathepsins in the Processing, Activation and Inactivation of Perforin
Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) recognize virus-infected or malignant transformed cells and destroy them through two independent mechanisms. Apoptotic target-cell death can be triggered by the engagement of death-receptors or by the release of cytotoxic granules. Cytotoxic granules gather at the site of contact between the …
Regulation of cysteine proteases cathepsins B, S and K and their role in inflammatory processes
Proteases are responsible for enzymatic cleavage of peptide bonds, which is a basic requirement for completion of diverse biological processes.The proteolytic activity of proteases must be rigorously controlled to avoid inappropriate degradation of proteins. Imbalance in regulation of proteolytic activity can be found in a wide range of diseases. Degradation …
Role and significance of cysteine cathepsins in different models of apoptosis
Programmed cell death is a highly organized process by which multicellular organisms eliminate damaged, superfluous and potentially harmful cells. Apoptosis is the most studied form of programmed cell death. It is characterized by typical morphological and biochemical changes which are a consequence of activation of cysteine proteases, caspases. Apoptosis is …