This dissertation examines the ecological dynamics of phytoplankton communities in the northern Adriatic Sea, focusing on phenology, environmental drivers, and trophodynamics. The complexity of the region, characterized by the richness of phytoplankton communities, environmental variability and intensive human activities, is not seen as an obstacle but as an opportunity to …
Magnetic resonance imaging (MRI) is a diagnostic method that is used for broad range of hospitalized patient, emergency patients, chemotherapy treated and as well the patients that may have infectious diseases. Because the examinations of different patients are usually performed with the same equipment in the same environment, the surfaces …
Lipid droplets (LDs) are intracellular organelles that store lipids, mainly triacylglycerols (TAGs) and sterol esters. LDs were initially considered just inert fat reservoirs but have now been identified as critical players in the cellular stress response, especially in cancer cells. In response to various kinds of stress, including nutrient deprivation …
The present thesis considers the premise that breath-holding in aquatic sports, primarily swimming, in order to enhance performance, can potentially cause adaptation to tissue hypoxia. To investigate this theory, a series of studies needed to be performed: I. Analysis of variability in individuals’ responses to hypoxia, to evaluate the range …
In the field of biomedical materials, conventional approaches to tissue engineering and wound healing face limitations that encourage the exploration of innovative treatments. This work presents multifaceted exploration of piezoelectric polylactic acid (PLA) films intended for biomedical applications, from the optimization of the conditions for efficient film preparation to the …
RNA molecules dynamically interact with RNA-binding proteins (RBPs), which control various aspects of RNA fate, such as its processing, localisation, and stability. Intricate networks of protein-RNA interactions thereby regulate gene expression and have a profound effect on downstream cellular processes. Most RBPs recognise specific motifs on their bound RNAs, characterised …
Epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases and plays an essential role in cell differentiation, migration, proliferation, and metabolism. Alterations in EGFR signalling were found in a number of cancers like lung, breast, colorectal cancer and gliomas, shown to be more aggressive and …
Glioblastoma (GB) is the most common and aggressive primary tumour of the central nervous system. Despite maximal possible surgical resection of the tumours and aggressive treatment regimens with radiotherapy and chemotherapy, patient overall survival is less than 2 years, as patients eventually develop resistance to therapy, resulting in recurrent tumours. …
Electrochemical energy conversion devices such as fuel cells (FCs) and water electrolyzers (WE) have attracted attention from the scientific community for their unique ability to store electrical energy in the form of hydrogen and then generate electricity by the reverse process. Unfortunately, those devices rely on a significant amount of …
We are speeding full throttle towards a climate catastrophe and we have only until 2030 to take action to avoid the most devastating and unimaginable consequences. The lack of political and corporate will to change the status quo of “business as usual” is causing mass protests and civil disobedience globally. …