Search Results (6)
Interplay between autophagy and lipid droplets in starving cancer cells
Lipid droplets (LDs) are intracellular organelles that store lipids, mainly triacylglycerols (TAGs) and sterol esters. LDs were initially considered just inert fat reservoirs but have now been identified as critical players in the cellular stress response, especially in cancer cells. In response to various kinds of stress, including nutrient deprivation …
In silico approach to understanding the mechanism of action and chemical toxicity prediction on human aromatase enzyme
Aromatase is an enzyme member of the cytochrome P450 superfamily coded by the CYP19A1 gene. Its main biological function in humans is the conversion of androgens into estrogens, transforming androstenedione into estrone and testosterone into estradiol. This enzyme is present in several tissues, and it has a key role in …
Role and significance of cysteine cathepsins in TRAIL induced apoptosis
Apoptosis is an innate mechanism by which a multicellular organisms eliminates unwanted, damaged and potentially harmful cells. During apoptosis inflammation of the surrounding tissues is prevented. Defects in an apoptotic signaling can lead to numerous pathological conditions. Apoptosis is mediated through two main pathways, the extrinsic or the death receptor …
Comparative View into Protease - Inhibitor Interaction
Interactions between macromolecules are the basic events of life. Their characterization is thus a key to understanding the physiology and the underlying specificity of these events. Not only understanding of the final states (where the molecules get closest together), also understanding of the course of approach is mandatory to gain …
Selenocompounds in selenium-enriched plants determined by spectrometric methods
Selenium (Se) has been demonstrated to be an essential trace element for maintenance of animal and human health. Se is incorporated into proteins to make selenoproteins, which are important antioxidant enzymes. The antioxidant properties of selenoproteins help to prevent cellular damage caused by radicals. Radicals are natural by-products of oxygen …
Regulation of cysteine proteases cathepsins B, S and K and their role in inflammatory processes
Proteases are responsible for enzymatic cleavage of peptide bonds, which is a basic requirement for completion of diverse biological processes.The proteolytic activity of proteases must be rigorously controlled to avoid inappropriate degradation of proteins. Imbalance in regulation of proteolytic activity can be found in a wide range of diseases. Degradation …