Search Results (48)
Comparative View into Protease - Inhibitor Interaction
Interactions between macromolecules are the basic events of life. Their characterization is thus a key to understanding the physiology and the underlying specificity of these events. Not only understanding of the final states (where the molecules get closest together), also understanding of the course of approach is mandatory to gain …
Ion Beam Modification of Surfaces in the Nanoscale Domain
Ion beam sputtering induces morphological as well as compositional changes on the surfaces of ion-sputtered substrates. The surface undergoes kinetic processes, which lead to different morphological details: periodic ripples, substrate-defined etch pits or protuberant structures, roughening and smoothing are some possibilities for surface evolution. The aim of my doctoral dissertation …
Regulation of cysteine proteases cathepsins B, S and K and their role in inflammatory processes
Proteases are responsible for enzymatic cleavage of peptide bonds, which is a basic requirement for completion of diverse biological processes.The proteolytic activity of proteases must be rigorously controlled to avoid inappropriate degradation of proteins. Imbalance in regulation of proteolytic activity can be found in a wide range of diseases. Degradation …
Na0.5Bi0.5TiO3-based materials with mechanical-stress-dependent dielectric properties
The stress dependence of the electrical permittivity offers a convenient way of measuring pressure. This effect is suitable for static and quasi-static stress applications, where the conventional method based on the piezoelectric effect becomes inadequate. Although the principle of applying this effect for pressure sensing has been known for almost …
Analysis of bacteria damages caused by treatment with oxygen plasma particles
The possible mechanisms for destruction of two types of bacteria with oxygen radicals were studied. Samples consisting of standard ATCC strains of Gram – positive bacteria Staphylococcus aureus and Gram – negative bacteria Escherichia coli were obtained. Bacteria were cultivated according to the standard procedures and fixed on substrates of …
Network Models of Self-Assembled Functional Materials
The fabrication of functional materials composed of metallic nanoparticles is one of the most important steps in the contemporary nanotechnology. Nonlinear selfassembly of nanoparticles into macroscopic aggregates are promising methods in which various structures can be obtained by tuning certain control parameters. Such large-scale aggregates exhibit new physical features, which …
Modular gene dynamics and network theory at mesoscopic scale
Complex dynamical systems are often modeled as networks, with nodes representing dynamical units which interact through the network’s links. Gene regulatory networks, responsible for the production of proteins inside a cell, are an example of system that can be described as a network of interacting genes. The behavior of a …
Functional interpretation of gene expression data
Microarrays are at the center of a revolution in biotechnology, allowing researchers to simultaneously monitor the expression of tens of thousands of genes. The final aim of a typical microarray experiment is to find a molecular explanation for a given macroscopic observation (e.g., which pathways are affected by the loss …