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In silico approaches to understand and predict the ligand-binding interactions of the human P-glycoprotein (ABCB1) membrane transporter

Author(s): Liadys Mora Lagares (Author), Marjana Novič (Supervisor), Emilio Benfenati (Co-Supervisor)

Year: 2021

Type: Doctoral dissertation

The P-glycoprotein (P-gp) is responsible for the elimination of a wide variety of substances from the cell, thus it is thought to play an important role in detoxification functions. The P-gp also affects the ADMET (absorption, distribution, metabolism, excretion, and toxicity in pharmacokinetics) properties of drugs. It is involved in …

Liquid-crystal microdroplets as optical microresonators and lasers

Author(s): Igor Muševič (Author), Matjaž Humar (Author)

Year: 2012

Type: Doctoral dissertation

This thesis investigates the use of single liquid-crystal droplets as optical microresonators and lasers. We have shown that liquid-crystal droplets can support a number of different optical modes that can be excited by introducing a fluorescent dye in the liquid crystal material and using an external excitation source of light. …