Search Results (20)
Unravelling the molecular mechanisms of plant-pathogen interactions in grapevine and potato through functional analysis
Plants are constantly exposed to various environmental stressors. Pathogen infections causing disease can affect economically important crops and impact global food production. To counter disease development and spread, it is imperative that we acquire a thorough knowledge of its pathogenesis, as well as of the mechanisms underlying plant immune response. …
Development and application of a non-targeted screening workflow for chemical exposure assessment in human biomonitoring and related studies
Human exposure to environmental stressors is widespread. Highly dynamic, these chemical, physical and social factors, collectively termed as the exposome, interact with internal factors such as genetics, sex, gut microbiome and general health status, and dictate susceptibility and risk for an onset of diseases. Human exposure to the chemicals is …
Targeted analysis of organic contaminants, exposure assessment, and vulnerability of populations to hazardous compounds
From the moment of conception until death, humans are exposed to chemicals at varying intensities and frequencies. While an individual’s level of resilience is commonly high enough to tolerate these kinds of stressors, specific exposures or genetic predispositions can lower it. Therefore, the assessment of chemical exposure, the development of …
Development of novel 3D in vitro cell models for genotoxicity assessment
The determination of genotoxicity is an important element in the safety assessment of various substances, with the purpose of preventing a number of chemicals from affecting human health. Genotoxicity testing is required for all classes of chemicals, drugs and biological agents, which can lead to a wide range of diseases, …
Role and significance of cysteine cathepsins in TRAIL induced apoptosis
Apoptosis is an innate mechanism by which a multicellular organisms eliminates unwanted, damaged and potentially harmful cells. During apoptosis inflammation of the surrounding tissues is prevented. Defects in an apoptotic signaling can lead to numerous pathological conditions. Apoptosis is mediated through two main pathways, the extrinsic or the death receptor …
Sonochemical synthesis and characterization of hydroxyapatite/metal-based composite materials for biomedical applications
A new approach for the synthesis of silver (Ag), platinum (Pt) and gold (Au) nanoparticles and their composites with hydroxyapatite (HAp) is developed via a sonochemical process. The major goal was to design physicochemical properties of material in order to achieve: (i) intensive antibacterial activity and (ii) maximal reduction of …
Effect of ingested nanofibers and nanoparticles on digestive gland epithelium of a model test organism
Engineered nanofibers and nanoparticles are recognized as capable of inducing cellular perturbations according to the oxidative stress paradigm or by interacting directly with biological membranes. A number of authors in their investigations with the nanofibres and nanoparticles has reported the ability of nanofibers and nanotparticle to cause the different damage …
Structural and electrical properties of 0.65PMN-0.35PT thick films on different substrates
A starting powder with the nominal composition 0.65Pb(Mg1/3Nb2/3)O3–0.35PbTiO3 (0.65PMN–0.35PT), which corresponds to the morphotropic phase boundary (MPB) composition, was prepared by mechanochemical activation followed by attritor milling and low-temperature calcination at 700°C. It had a narrow particle size distribution with the median particle size equal to 0.3 μm. From the …
Na0.5Bi0.5TiO3-based materials with mechanical-stress-dependent dielectric properties
The stress dependence of the electrical permittivity offers a convenient way of measuring pressure. This effect is suitable for static and quasi-static stress applications, where the conventional method based on the piezoelectric effect becomes inadequate. Although the principle of applying this effect for pressure sensing has been known for almost …
Role and significance of cysteine cathepsins in different models of apoptosis
Programmed cell death is a highly organized process by which multicellular organisms eliminate damaged, superfluous and potentially harmful cells. Apoptosis is the most studied form of programmed cell death. It is characterized by typical morphological and biochemical changes which are a consequence of activation of cysteine proteases, caspases. Apoptosis is …