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Validation of peptides as protein substrate models for specificity studies of cysteine cathepsins
Cysteine cathepsins are endosomal proteases that are involved in lysosomal protein degradation. Additionally, they engage in specific biological processes, like bone degradation (CatK), antigen presentation (CatS) and pro-hormone processing (CatV and CatL). Their enhanced activity was described in numerous pathological states, like cancer and viral activation, which made them promising …