Search Results (4)
Interplay between autophagy and lipid droplets in starving cancer cells
Lipid droplets (LDs) are intracellular organelles that store lipids, mainly triacylglycerols (TAGs) and sterol esters. LDs were initially considered just inert fat reservoirs but have now been identified as critical players in the cellular stress response, especially in cancer cells. In response to various kinds of stress, including nutrient deprivation …
Quantitative imaging of cisplatin in tumour samples by laser ablation inductively coupled plasma mass spectrometry
Medicine relies on imaging techniques such as ultrasound, magnetic resonance, computed tomography and histopathological image analysis because they provide valuable data needed for the diagnosis and treatment of diseases and injuries. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is often used in research and for the advanced diagnosis and …
Speciation of ruthenium-based candidate drugs for cancer treatment and copper as a potential biomarker for cancer diagnosis in human serum
According to the World Health Organization (WHO), cancer represents the second leading cause of mortality, with almost 10 million deaths in 2020. A broad spectra of cancer treatments are being developed, among them are metal-based drugs. Consistent with the available data, platinum (Pt)-based chemotherapeutics are still widely used to treat …
Contribution to understanding of the mechanism of amyloid fibril formation and its effects on the cell
The presence of insoluble amyloid aggregates in various human tissues correlates with the development of many human disorders (amyloidoses), including neurodegenerative diseases. Deposition of the aggregated misfolded proteins in the brain, where aggregates can be localized extracellularly or intracellularly, is the main characteristic of Alzheimer's, Parkinson's, Huntington's, prion diseases and …