Unexpected production breakdowns and unpredictable defects in product quality remain critical problems in modern manufacturing systems. Usually occuring by no obvious exterior cause and often during periods of smooth production, they lead to production losses and reduced process availability, which results in lower profit rates. Conventional statistical methods of process …
The number and variety of macromolecular structures in complexes with "hetero" ligands is growing. The need for fast delivery of correct geometric parameters for their refinement, which is often crucial for understanding the biological relevance of the structure, is growing correspondingly. The current standard for describing protein structures is the …
Microarrays are at the center of a revolution in biotechnology, allowing researchers to simultaneously monitor the expression of tens of thousands of genes. The final aim of a typical microarray experiment is to find a molecular explanation for a given macroscopic observation (e.g., which pathways are affected by the loss …