Search Results (39)
In silico approach to understanding the mechanism of action and chemical toxicity prediction on human aromatase enzyme
Aromatase is an enzyme member of the cytochrome P450 superfamily coded by the CYP19A1 gene. Its main biological function in humans is the conversion of androgens into estrogens, transforming androstenedione into estrone and testosterone into estradiol. This enzyme is present in several tissues, and it has a key role in …
Interactions of azole molecules with copper ions and copper surfaces covered with chemisorbed H, O, Oh or Cl
In real environments, copper and other metal surfaces are never clean. Even during active dissolution in corrosion, they are likely to be covered with adsorbed corrosion-relevant species such as O, OH, H, and Cl. To explore the impact of such species on the bonding of imidazole, used herein as an …
Validation of peptides as protein substrate models for specificity studies of cysteine cathepsins
Cysteine cathepsins are endosomal proteases that are involved in lysosomal protein degradation. Additionally, they engage in specific biological processes, like bone degradation (CatK), antigen presentation (CatS) and pro-hormone processing (CatV and CatL). Their enhanced activity was described in numerous pathological states, like cancer and viral activation, which made them promising …
Optimization and application of MeV time-of-flight secondary ion mass spectrometry in the standard and low primary ion beam energy mode
Time-of-flight secondary ion mass spectrometry using MeV ions (MeV ToF SIMS) has been around for a few decades as a reliable, surface-sensitive method for the detection of molecular ions having masses up to 1000 Da. It provides excellent lateral resolution of a few μm for imaging of organic samples, making …
Unravelling the molecular mechanisms of plant-pathogen interactions in grapevine and potato through functional analysis
Plants are constantly exposed to various environmental stressors. Pathogen infections causing disease can affect economically important crops and impact global food production. To counter disease development and spread, it is imperative that we acquire a thorough knowledge of its pathogenesis, as well as of the mechanisms underlying plant immune response. …
Study of inconsistencies in health risk assessment: the role of assessment context in decision analysis aimed at their reduction
The area of risk assessment continues to be challenged by foundational issues that limit its potential to inform public health decisions. This doctoral work improves our understanding of the interaction between science and public and environmental health policy by addressing specific challenges in risk assessment within and for decision-making. The …
Atmospheric pressure plasma jet deposition of nanoparticles and its applications
Atmospheric pressure non-equilibrium plasma jets in material processing have received substantial attention in the past two decades and are still in the developing stage with a growing interest in material synthesis and surface processing. The main opportunities of these techniques are their potential cost reductions in apparatus and handling. Because …
Low-Pressure Plasma Functionalisation of Fluoropolymers
In the present thesis, the problem of the functionalisation of fluoropolymers was addressed. As chemical methods for the functionalisation of fluoropolymers apply environmentally harmful chemicals, the research was directed to low-pressure non-equilibrium radiofrequency (RF) inductively coupled plasmas of environmentally friendly gasses. The research was focused on polytetrafluoroethylene (PTFE), the most …
Mechanisms for colloidal stabilization of magnetic nanoplatelets
The dissertation presents a study of the colloidal stabilization of ferrimagnetic barium hexaferrite nanoplatelets in various isotropic and nematic media for the preparation of ferromagnetic fluids. Colloidal stability is the most important requirement to obtain a ferromagnetic liquid of barium hexaferrite nanoplatelets that exhibits spontaneous magnetization in the absence of …
Characteristics of gaseous plasma in a large low-pressure reactor
The scientific backgrounds of technologies involved in the production of headlamps for the automotive industry are elaborated in this thesis. The experimental work was performed using an industrial plasma reactor with a volume of approximately 5 m3. The reactor enables three different operations, i.e., plasma pretreatment of workpieces made from …