Search Results (4)
In silico approach to understanding the mechanism of action and chemical toxicity prediction on human aromatase enzyme
Aromatase is an enzyme member of the cytochrome P450 superfamily coded by the CYP19A1 gene. Its main biological function in humans is the conversion of androgens into estrogens, transforming androstenedione into estrone and testosterone into estradiol. This enzyme is present in several tissues, and it has a key role in …
Low-Pressure Plasma Functionalisation of Fluoropolymers
In the present thesis, the problem of the functionalisation of fluoropolymers was addressed. As chemical methods for the functionalisation of fluoropolymers apply environmentally harmful chemicals, the research was directed to low-pressure non-equilibrium radiofrequency (RF) inductively coupled plasmas of environmentally friendly gasses. The research was focused on polytetrafluoroethylene (PTFE), the most …
Development and application of a non-targeted screening workflow for chemical exposure assessment in human biomonitoring and related studies
Human exposure to environmental stressors is widespread. Highly dynamic, these chemical, physical and social factors, collectively termed as the exposome, interact with internal factors such as genetics, sex, gut microbiome and general health status, and dictate susceptibility and risk for an onset of diseases. Human exposure to the chemicals is …
Development of analytical methods for speciation of organotin compounds in environmental samples using gas chromatography and mass spectrometry
Organotin compounds (OTCs) are the organometallic compounds with the most numerous applications. Today, it is more than 50 years of their intensive development and use. While they are highly useful chemicals they are also extremely toxic to a wide array of aquatic and terrestrial living organisms at very low concentrations. …