Search Results (107)
Unravelling the molecular mechanisms of plant-pathogen interactions in grapevine and potato through functional analysis
Plants are constantly exposed to various environmental stressors. Pathogen infections causing disease can affect economically important crops and impact global food production. To counter disease development and spread, it is imperative that we acquire a thorough knowledge of its pathogenesis, as well as of the mechanisms underlying plant immune response. …
Electron microscopy of titanium oxynitride supported iridium based electrocatalysts
We are speeding full throttle towards a climate catastrophe and we have only until 2030 to take action to avoid the most devastating and unimaginable consequences. The lack of political and corporate will to change the status quo of “business as usual” is causing mass protests and civil disobedience globally. …
Characterization of plant viromes using different viral nucleic acids enrichment strategies and high-throughput sequencing platforms
Plant viruses are very important plant pathogens, causing economic losses by infecting cultivated plants, causing diseases, and consequently reducing crop quality and quantity. In recent years, the development of high throughput sequencing (HTS) technologies has dramatically broadened the possibilities for plant virus research and diagnostics, enabling the discovery of new …
Study of inconsistencies in health risk assessment: the role of assessment context in decision analysis aimed at their reduction
The area of risk assessment continues to be challenged by foundational issues that limit its potential to inform public health decisions. This doctoral work improves our understanding of the interaction between science and public and environmental health policy by addressing specific challenges in risk assessment within and for decision-making. The …
Annotation of semi-polar organic contaminants by using gas chromatography coupled to mass spectrometry and machine learning
Contaminants of emerging concern (CECs), representing a subgroup of organic compounds of natural or synthetic origin, and their degradation and transformation products (TPs), with potentially harmful effects on humans, biota, and the environment, are the eco-exposome (EE) constituents of utmost importance. Their identification, quantification, and continued investigation into their environmental …
Atmospheric pressure plasma jet deposition of nanoparticles and its applications
Atmospheric pressure non-equilibrium plasma jets in material processing have received substantial attention in the past two decades and are still in the developing stage with a growing interest in material synthesis and surface processing. The main opportunities of these techniques are their potential cost reductions in apparatus and handling. Because …
Investigating the early molecular events following exposure of lung cells to nanoparticles using advanced optical microscopies
The potential toxicity of nanoparticles in our environment and consumer products is currently determined by costly and timely animal-based testing, which limits the rate of nanoparticle testing, causing a desperate need for alternative testing strategies. A promising alternative – mechanism-based prediction – employs a set of high-throughput cell-based tests that …
Speciation of ruthenium-based candidate drugs for cancer treatment and copper as a potential biomarker for cancer diagnosis in human serum
According to the World Health Organization (WHO), cancer represents the second leading cause of mortality, with almost 10 million deaths in 2020. A broad spectra of cancer treatments are being developed, among them are metal-based drugs. Consistent with the available data, platinum (Pt)-based chemotherapeutics are still widely used to treat …
Protection of biomedical alloys by thin films of alumina and hafnia prepared by atomic layer deposition
One of the most commonly used metal materials for the manufacture of biomedical implants are stainless steel and titanium-based alloys. Due to the specific conditions and complex environment in the human body, different strategies have been employed to protect them and improve their functionality in vivo. In this thesis, a …
User experience evaluation of novel air quality sensing technologies for citizen engagement in environmental health studies
The use of low-cost sensing technologies increasingly used in participatory environmental health studies brings both opportunities and challenges. While previous research mostly focused on technical aspects, this thesis brings participants to the foreground and articulates their experiences. It aims to evaluate if low-cost sensing technologies are fitfor- purpose in environmental …