Search Results (2)
In silico approaches to understand and predict the ligand-binding interactions of the human P-glycoprotein (ABCB1) membrane transporter
The P-glycoprotein (P-gp) is responsible for the elimination of a wide variety of substances from the cell, thus it is thought to play an important role in detoxification functions. The P-gp also affects the ADMET (absorption, distribution, metabolism, excretion, and toxicity in pharmacokinetics) properties of drugs. It is involved in …
Occurrence, fate and removal of pharmaceutical residues in water treatment
The presence of pharmaceutical residues in surface waters is an emerging environmental issue that provides a new challenge to treatment systems for potable water, wastewater and water reuse. Their principle pathways into the sewerage system are twofold: first, after being administered to patients they are normally excreted as various metabolites …