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Licit and illicit drugs in waste- and environmental waters: epidemiological and environmental implications

Author(s): Taja Verovšek (Author), Ester Heath (Supervisor)

Year: 2023

Type: Doctoral dissertation

The analysis of drug residues in waste and environmental waters offers valuable insights into the epidemiological and environmental implications of drug use. This study employs a wastewater-based epidemiology (WBE) approach to estimate the use of licit and illicit drugs and new psychoactive substances (NPS) among both general and specific populations. …

Development and employment of untargeted and targeted tools for virus detection in the frame of water-based epidemiology

Author(s): Olivera Maksimović (Author), Jon Gutiérrez-Aguirre (Supervisor), Denis Kutnjak (Co-Supervisor)

Year: 2023

Type: Doctoral dissertation

Traditional methods of studying viruses are limited in their ability to detect novel pathogens, but recent advances in high-throughput sequencing (HTS) are changing that. HTS allows researchers to probe deeply into the virome of various hosts and environments, identifying known and unknown viral species. However, a targeted approach, like quantitative …

Development and application of molecularly imprinted polymers for selected antidepressants and studies of their environmental fate

Author(s): Tjaša Gornik (Author), Tina Kosjek (Supervisor), Ester Heath (Co-Supervisor)

Year: 2022

Type: Doctoral dissertation

This thesis focuses on the fate of chosen antidepressants in the environment. Studied compounds belong to the class of selective serotonin reuptake inhibitors. Reportedly they do not completely mineralize by existing water treatment processes and their residues cause unwanted toxic effects in aquatic organisms. However, to date, insufficient information has …

Annotation of semi-polar organic contaminants by using gas chromatography coupled to mass spectrometry and machine learning

Author(s): Milka Ljoncheva (Author), Tina Kosjek (Supervisor), Sašo Džeroski (Co-Supervisor)

Year: 2022

Type: Doctoral dissertation

Contaminants of emerging concern (CECs), representing a subgroup of organic compounds of natural or synthetic origin, and their degradation and transformation products (TPs), with potentially harmful effects on humans, biota, and the environment, are the eco-exposome (EE) constituents of utmost importance. Their identification, quantification, and continued investigation into their environmental …

The use of high-throughput sequencing for detection of viral sequences in complex samples from environment and industry

Author(s): Katarina Bačnik (Author), Maja Ravnikar (Supervisor), Denis Kutnjak (Co-Supervisor)

Year: 2022

Type: Doctoral dissertation

Metagenomics based on high throughput sequencing (HTS) has opened a new era of discovery and genomic characterization of viruses associated with a given host or environment. The search for novel viral sequences provides an excellent opportunity to improve early detection of pathogens, and to predict viral hosts and environmental reservoirs …

Development and application of a non-targeted screening workflow for chemical exposure assessment in human biomonitoring and related studies

Author(s): Žiga Tkalec (Author), Tina Kosjek (Supervisor)

Year: 2022

Type: Doctoral dissertation

Human exposure to environmental stressors is widespread. Highly dynamic, these chemical, physical and social factors, collectively termed as the exposome, interact with internal factors such as genetics, sex, gut microbiome and general health status, and dictate susceptibility and risk for an onset of diseases. Human exposure to the chemicals is …

Removal of contaminants of emerging concern using algal photobioreactors

Author(s): David Škufca (Author), Ester Heath (Supervisor)

Year: 2021

Type: Doctoral dissertation

Contaminants of emerging concern (CEC) are organic pollutants occurring in wastewater and consequently enter the environment. An alternative to conventional wastewater treatment are algal photobioreactors, which treat wastewater with low energy input while producing nutrient- and energy-rich algal biomass and treated water, which both have the potential to be reused. …

Ostanki bisfenolov v vodnem okolju: pojavnost in kroženje

Author(s): Ana Kovačič (Author), Ester Heath (Supervisor), Tina Kosjek (Co-Supervisor)

Year: 2021

Type: Doctoral dissertation

Bisphenols are a group of industrial chemicals increasingly recognized as contaminants of emerging concern because of their presence in the environment and endocrine disrupting effects. They are used in the production of polycarbonate plastic, epoxy resins and thermal paper, in most cases without restriction. The global exception is bisphenol A, …

Determination of steroid estrogens in environmental samples using chemical analysis (GC-MSD) and an in vitro estrogenicity assay (ER-Calux®)

Author(s): Miha Avberšek (Author), Ester Heath (Supervisor), Janez Ščančar (Co-Supervisor)

Year: 2012

Type: Doctoral dissertation

The presence of steroid estrogens in the environment has been studied intensively for two decades because of their possible deleterious effects on living organisms at very low (ng/L) concentrations. To determine concentrations of steroid estrogens and the estrogenic potential of environmental samples, sophisticated and sensitive analytical techniques as well as …

Occurrence, fate and removal of pharmaceutical residues in water treatment

Author(s): Tina Kosjek (Author), Ester Heath (Supervisor)

Year: 2009

Type: Doctoral dissertation

The presence of pharmaceutical residues in surface waters is an emerging environmental issue that provides a new challenge to treatment systems for potable water, wastewater and water reuse. Their principle pathways into the sewerage system are twofold: first, after being administered to patients they are normally excreted as various metabolites …